Sorry to hear of your problems. The biologicals have been a breakthrough for so many people w/arthritis. My rheumatologist says there are several more under development so try not to lose faith and hope. Lets hope that eventually, these drugs will lead to a cure or at least significant longer relief without wearing off. You mentioned being bummed about having to leave your job. You might check into doing some work at home from computer if you can tolerate it. Don't know much about it but seems like there are "legitimate" real jobs doing this. Best wishes,