In my case I had (so nice to be able to say "had") both pain and flexibility issues. After my first Humira shot I noticed improvement in flexibility first. But, I was doing stretching exercises for sometime before the shot and I knew the limits. I felt flexibilty increase after 3 hours of the first shot. It took a couple of weeks (my second shot) for the lingering pain areas (mostly the curved spine area between the shoulder blades) to settle down. Shot #3 is tomorrow and I am so happy the way things are now. I so hope you find the same happiness...just give it some more time.