Hi, I've been on methotrexate (mtx) since October 2011 and have been on 20mg per week for most of that time. I found the idea of it quite scary, but it's been good for me. It usually helps peripheral symptoms more than spinal symptoms and that's the case for me - it especially helps my hands more than anything else.

It's really important to just take it weekly (there have been fatal overdoses when people have not realised and taken it daily) and it's really important not to get pregnant as it has been linked to birth defects. You need to take folic acid - I had to increase it after a while as I was getting some digestive upset etc. And it is important to have regular blood tests to check it's not affecting your liver or blood count etc - I have a monthly blood test that also checks my inflammation (crp) levels.

I hope it works for you.

AS, IBS, reflux oesophagitis and dysphagia, PCOS/insulin resistance, asthma...
Currently managing my AS with humira, methotrexate, low starch diet and exercises. Also taking omeprazole, metformin etc.