Interestingly, some of the most significant non-MHC SNPs encode variants with a loss of function that confers protection against developing disease (eg. IL23R R381Q and ERAP1 rs30187).
Currently the number of AS-associated gene loci is about 30 and intriguingly many of these genes congregate along an immunomodulatory pathway.

Dx Oct 2006 B27+ undifferentiated spondlyarthropathy (uSpA) with mild sebhorrhoeic dermatitis and mild Inflammatory Bowel Disease (IBD) controlled by NSD since 2007.