Hi jroc and SimplySouthern,

I think you're reading that right jroc. Bad luck that you should have both the at-risk ERAP1 minor alleles for rs30187 and rs27044 - which is consistent with you being early onset mixed.
By contrast, you, SimplySouthern, have the major alleles for ERAP1 rs30187 and rs27044, that is, for these two SNPs you have the alleles that are not associated with AS.
As for rs7743761 - I think it's significance is lessened by the fact that it is on chromosome 6 - in or near HLA-B27.


Dx Oct 2006 B27+ undifferentiated spondlyarthropathy (uSpA) with mild sebhorrhoeic dermatitis and mild Inflammatory Bowel Disease (IBD) controlled by NSD since 2007.