Based on my results, the ERAP1 is not my strong suit but lends more 'bad' rupute towards IL23R. Do you have a method for the IL23R?
PS. I think the same concept when applied to IL23R will yield useful results. In the case of ERAP1 allotype pairs, cumulative loss of function is a risk factor for AS; whereas for IL23R, loss of function is protective against AS, because if IL23 can't engage functionally or properly with IL23R then inflammation will be shut down?