Originally Posted By DavidP
PS. I think the same concept when applied to IL23R will yield useful results. In the case of ERAP1 allotype pairs, cumulative loss of function is a risk factor for AS; whereas for IL23R, loss of function is protective against AS, because if IL23 can't engage functionally or properly with IL23R then inflammation will be shut down?

Based on my results, the ERAP1 is not my strong suit but lends more 'bad' rupute towards IL23R. Do you have a method for the IL23R?