Wow, that's complex stuff!
Are you up with the play on the latest HLA-B27 research with regards to arthritogenic peptide vs unfolded protein response vs cell surface homodimers? I haven't kept up to date with the research from the last couple of years, but back when I was reading all the papers it seemed to be a 3 horse race, and figuring out ERAP1's involvement looked like it was going to be the key to figuring the pathogenic mechanism of B27. From the look of this abstract it doesn't look like there have been any major breakthroughs -
http://www.annualreviews.org/doi/abs/10.1146/annurev-immunol-032414-112110
