The notion that gut bacteria can escape from the gut lumen and into the organs to form biofilms that evade the immune system is old news. Perforated guts that allow infection to get established in the peritoneum is not unheard of.
But just like having found the gene for male pattern baldness decades ago doctor still don't know what to do with it in cases of chronic illness when the microbe is not detectable.
In the past few months I have posted in these forums that our gut microbiota communicates with the reneged bacteria in our organs and I hypothesized that people that do not benefit from a NSD diet have extremely large populations of renegade bacteria in their organ tissue. High gut permeability, mast cell proliferation, and as many other factors that the imagination can conjure probably are good hypothesis too.
In the summer of 2015 I told the head of rheumatology at my favourite hospital that I believed that the use of NSAIDs allowed gut microbes to escape and get into my body resulting in spinal inflammation and other symptoms of AS. She said to me, "Yes. There are good bugs and there are bad bugs. I can get you to a doctor that can help you."
The look on her face and demeanor in her voice disturbed me. She promptly referred me to a psychiatrist. I hope to meet her in Hell. I have some bones to pick with her (for thousands of years!)
It is possible that many pathogens colonize our gut all our life but do not cause problems until the gut integrity is lost and the pathogen finds its way into our body. After that I think that targeted IV antibiotics is the best way to go to avoid damaging the gut biota. I wish a skin patch worked instead of a PICC line.
https://www.youtube.com/watch?v=v3lwhL4rEaALocating, identifying and specifically targeting microbes in humans is in its infancy. Within the past year using radio-tracers that are highly preferred by certain bacteria were used in a human experiment. The bacteria were located using PET.
https://www.sciencedaily.com/releases/2017/10/171005111111.htmI have noticed heavy use of IVs in small clinics in some Asian countries. I don't know what is in it but I do know that they are often going for treatments to lower inflammation.
