Kickas.org Forums Ankylosing Spondylitis General Discussion #1 AS Web Support Group hereditary AS

some say that the good ol' AS can be hereditary,right?

my silly question is can my father pass down AS to me even although i don't have the B27?

i of course have AS, my sister MAY have AS, and i recall when i was a youngster my father suffered terribly with back pains.AS for him was unDX and he wore corsets and slept on removed doors,i remember his pain and /screams/shouts all too well

Hmmm....did i get my AS from my dear ol' dad?

Hi, saltire:




Since the antigen causing Your AS is yet unidentified, there is still a 50% chance You inherited this condition from Your father and the same probability of course You inherited it from Your mother.

According to some experts, the basic onset of AS is inherited at the probability rate of "14%;" the rest--THEY believe--is "environmental." WE, however, claim to have identified that environmental factor.

If I had actually overcome AS, I would ask "how long can their eyes remain closed?!!" But I am too polite--oh!, wait! No I'm not...and yes I did!

HEALTH,
John

I would say that according to Bayesian statistics, given the extra knowledge that Saltire's father had agonizing back pains and his mother didn't... that the chance of his main AS susceptibility gene coming from father is a lot higher than 50%!

On the other hand, since there was no mention of a frozen spine, the additional genes that cause ankylosing rather than undiff spondylitis could easily have come from mother's side of the family.

Hi Saltire
Yes i think so, i did inherit it from my grandmother. But no one else in the generation in between had it. So its needs some more addition to hereditary to trigger it, may be the environment.

I personally wouldn't worry about the B27 gene. while helpful for dx when one has both it and the symptoms, not having it really doesn't mean anything at all.

my experience is that if i have the same symptoms for a disease that my relatives had / have, then its hereditary.

on my mother's side: both stomach inflammation leading to gastritis, ulcers, stomach cancer, and "arthritis" that starts in one's 30s. hmmm? hereditary? yes.

others seem to have the stomach inflammation worse while i seem to have the arthritis worse. but many of us have more or less the same symptoms.

if your dad had all those symptoms and you and your sister do as well, i don't see how that could be coincidental? unless one claims environmental factors. but then why doesn't everyone in that environment develop AS?