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Joined: Feb 2006
Posts: 1,483
drizzit Offline OP
Silver_AS_Kicker
OP Offline
Silver_AS_Kicker
Joined: Feb 2006
Posts: 1,483
For spinal AS this is very good news for TNF users who respond well to the drugs.


TNF drugs really are a miracle for many AS patients and looking better as time goes on for the ones they work for. (dealing with Spinal damage and progression)

Results
"TNFα inhibitor treatment was associated with a 50% reduction in the odds of progression, with an odds ratio (OR) of 0.52 (95% confidence interval [95% CI] 0.300.88, P = 0.02). Patients with a delay of >10 years in starting therapy were more likely to experience progression as compared to those who started earlier (OR 2.4 [95% CI 1.095.3], P = 0.03). In the ZINB model, the use of TNFα inhibitors significantly reduced disease progression when the gap between radiographs was >3.9 years. The protective effect of TNFα inhibitors was stronger after propensity score matching."

the full paper is available for those who want to read it. A good read


Wiley article


No families take so little medicine as those of doctors, except those of apothecaries.

Oliver Wendell Holmes
Joined: Sep 2001
Posts: 2,192
Major_AS_Kicker
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Major_AS_Kicker
Joined: Sep 2001
Posts: 2,192
That is good news, wish I could take TNF again.


Steve Orchard, Running from AS & MS
Joined: Jan 2008
Posts: 21,346
Likes: 1
Very_Addicted_to_AS_Kickin
Offline
Very_Addicted_to_AS_Kickin
Joined: Jan 2008
Posts: 21,346
Likes: 1
thanks for that, good to see this appears to be true smile



sue

Spondyloarthropathy, HLAB27 negative
Humira (still methylprednisone for flares, just not as often. Aleve if needed, rarely.)
LDN/zanaflex/flector patches over SI/ice
vits C, D. probiotics. hyaluronic acid. CoQ, Mg, Ca, K.
chiro
walk, bike
no dairy (casein sensitivity), limited eggs, limited yeast (bread)
Joined: Mar 2002
Posts: 9,522
Likes: 2
Offline
Joined: Mar 2002
Posts: 9,522
Likes: 2
Thanks for the note Steve.

With all those with positive results here and posting, figured that could be the case.

Tim


AS may win some battles, but I will win the war.

KONK - Keep ON Kicking
Joined: Feb 2011
Posts: 1,968
Pea Offline
Captain_AS_Kicker
Offline
Captain_AS_Kicker
Joined: Feb 2011
Posts: 1,968
Thank's Steve.


Pea
Diagnosed with A.S. 29 year's ago.
Diagnosed with Fibro 10 year's ago.
Remicade, Intrathecal Pain Pump 2013
Joined: Jan 2010
Posts: 2,105
C
Major_AS_Kicker
Offline
Major_AS_Kicker
C
Joined: Jan 2010
Posts: 2,105
anecdotally it always seemed that antitnfs were doing a whole lot better than most other things, and logically if they were substantially relieving the pain, then its hard to believe they weren't actually slowing down disease. I'm glad the research is finally coming through.


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