I think this is a personal decision. For me, since I have three kids and they all still need me. The cancer risk scares me. If LSD/NSD helps, I would try that first for now. However, if my kids are all adults, it would be a lot easier for me to make a decision to take Anti TNF. I agree with one said AS is not deadly but cancer is. On the other hand, living a server painful life is extremely tough! So it is a very tough personal decision to make.