My rheumy said to take it all at once. I take it at night before bed on Friday. The first dose gave me a bit of an odd feeling in tummy, but no nausea. Since then, no side-effects at all. And take the folic acid all the other 6 days. I still can't find a link online regarding this, though there was some discussion about how to do this, and how much folic acid is needed to protect the red cells.
It was about a month on MTX before I thought there could be some benefit. It had done me some good. I know this because when I have to stop to take antibiotics (usually a couple of sinus infections over the winter), I lose ground.
Good luck with it.
DX: Psoriatic Arthritis, Osteoporosis, Psoriasis
Meds: MTX since Oct 2009, 15mg/week. Cimzia-restarted after 2 yrs away.
Epidural Steroid Injections x8; Lumbar Radiofreq Ablation x2
SIJ Steroid Injection x3; Bilateral Radiofreq Ablation SIJ x9
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