I've used in a couple of recipes and I didn't have any pain level increase but the last time I used it, I got very sick to my stomach within a couple of hours. Maybe related to the nutritional yeast, maybe not.

I have read that you shouldn't eat more than a certain amount a day (I can't remember what that is but I want to say a couple tbsp). It does make whatever you're cooking taste good but I haven't used it since.