I don't take Enbrel so what I'm about to say may not be reliable.

Enbrel is an antibody treatment directed against TNF and raised in an animal like hamsters. Hamster immunoglobulin is a foreign protein to us so often patients will develop antibodies against hamster immunoglobulins and so the patient will effectively become refractory to Enbrel after a period.

Hopefully people who take the biologics will know more about this scenario and be able to give more details relating to the loss of effectiveness of Enbrel.

Regards David

Dx Oct 2006 B27+ undifferentiated spondlyarthropathy (uSpA) with mild sebhorrhoeic dermatitis and mild Inflammatory Bowel Disease (IBD) controlled by NSD since 2007.