Hello, ramakentesh:

Certainly, it has been my own experience that AS was at its worst and most severe in earliest stages; the first decade was by far the worst! Many others have experienced this, also, and the reasons are probably associated with the nature of the advancing disease: Characteristically beginning within the largest structures (proximal in fact to the primary lesion), but as these collagens become consumed, the inflammatory reaction self-limits, due to byproducts and restriction of diffusion (pedesis) the disease becomes less active in the most painful areas, and activity moves up the spinal column into smaller spaces.

This does not mean that AS damage is reduced to any extent; it is just that the pains seem worse over the first several years, but it is more than just becoming 'accustomed' to the pain--more than simple perception; it is actually because the SIJ pain, sacroiliitis, and sciatica really reduce.

Nor do I mean that 'fusion stops pain;' but essentially the pains can reduce once the skeletal damage limits our motion and changes our Osp enough that cells do not die as often or as many.

"To some extent" the pain from AS becomes more manageable and less intense; I experienced this long before NSD results.

HEALTH,
John

But the reasons for this are