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If you want to use this QR code (Quick Response code) just save the image and paste it where you want. You can even print it and use it that way. Coffee cups, T-Shirts etc would all be good for the QR code.
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Joined: Apr 2011
Posts: 105
Journeyman_AS_Kicker
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Journeyman_AS_Kicker
Joined: Apr 2011
Posts: 105 |
Just wondered if others knew what HlA B27 subtypes they were. Im HLA B2717. Also curious if people had to out of pocket the test how much did it cost?
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Joined: Aug 2011
Posts: 501
Veteran_AS_Kicker
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Veteran_AS_Kicker
Joined: Aug 2011
Posts: 501 |
My subclass is 16 - I not sure where it originated from - there are two other subclasses which they are not sure they originated from either.
Hugs
KickAS member since 04/22/06
Psoriasis(72), AS(2006), PsA with Spondylitis(2011),Vitiligo (69), sleep apnea (2004), Bronchial Asthma, many allergies, anaphylaxis allergy to sulfites, diabetic, Vitamin D deficient - Celiac/fructose intolerance/malabsorption - many co-morbidities
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Joined: Sep 2007
Posts: 608
Master_Sergeant_AS_Kicker
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Master_Sergeant_AS_Kicker
Joined: Sep 2007
Posts: 608 |
The below is from a 2009 publication
HLA-B27 represents a family of 38 closely related cell surface proteins (encoded by the alleles HLA-B*2701-39) called subtypes of HLA-B27, most of which evolved from the ubiquitous HLA-B*2705 (specifically the B*27052 allele). HLA-B27 subtypes are largely characterised by nucleotide substitutions (mostly nonsynonymous)in exons 2 and 3 which encode the alpha1 and alpha2 domains of the peptide binding groove respectively.
Subtypes with substitutions in the First Domain (alpha1)
HLA-B*2702, the most frequently occuring allele of this group, occuring primarily in those of Middle Eastern, Northern African and European ancestry. It is restricted to Caucasoids and accounts for 5-10% of HLA-B27 subtypes in Europeans.
HLA-B*2703 - next most common of this group - most likely evolved in West Africa ......
HLA-B*2716, first described in Causcasians, differs from B*2705 at three amino acids at positions 69, 70 and 71 - and has no known disease association to date.
Other members of this group are quite rare and probably evolved recently, characterised by a single nucleotide mutation, including HLA-B*2716, B*2737 and B*2739, which likely evolved directly from B*2705. HLA-B*2717 shows one mismatch at position 248(A->T), considered to be a conserved position in nearly all B alleles, which results in a phenyalanine for tyrosine substitution
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I don't think HLA-B27 subtyping is done commercially - probably just a research tool.
Dx Oct 2006 B27+ undifferentiated spondlyarthropathy (uSpA) with mild sebhorrhoeic dermatitis and mild Inflammatory Bowel Disease (IBD) controlled by NSD since 2007.
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Joined: Sep 2007
Posts: 608
Master_Sergeant_AS_Kicker
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Master_Sergeant_AS_Kicker
Joined: Sep 2007
Posts: 608 |
A correction to my last comment
the bracket ... 'including HLA-B*2716, B*2737 and B*2739' should have read 'including HLA-B*2717, B*2737 and B*2739'
oops
Dx Oct 2006 B27+ undifferentiated spondlyarthropathy (uSpA) with mild sebhorrhoeic dermatitis and mild Inflammatory Bowel Disease (IBD) controlled by NSD since 2007.
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