Thanks Cindy. As far as all the problems with the liver and the lupus symptoms, the Dr. never said that it was the Embrel, He just took me off in a flash. I know the weight gain was a side affect. Yes the problems are still going on. My liver is getting worse and now I am not clotting very well. I am not getting any answers from any of the Dr's I have seen. I am on alot of anti depressives because I am having a hard time dealing with the debilitating pain and the change of life quality. Oh well. I had a whole 2 years on Embrel and it was wonderful. I am grateful for that. Oh yeah if you get the flu you should tell the Dr. because we are dealing with an autoimmune disorder and if you go off for a few days it won't hurt, you will not notice any difference. Good Luck to all. Rose