here, this may help:
http://hmg.oxfordjournals.org/content/9/11/1563.fullother papers too, if one googles "CYP2D6 spondyloarthropathy" but most require subscription to access.
apparently there is a link to CYP2D6 polymorphisms and spondyloarthropathy.
i am HLAB27 negative, appear to have undiff spondy rather than AS, and have suspected that i was a "poor metabolizer" when it comes to this P450 based on my inability to process codeine (when given codeine, it knocked me out, but had absolutely no analgesic affect what so ever. years later when reading about CYP2D6 polymorphisms, i felt like i was reading about myself.)
interesting, i wonder if this is my link: CYP2D6 mutations and undiff spondy. wonder what exactly the connection is?
as for which P450(s) metabolize the biologics? just some quick googling, appears to be other P450s. that's good news for me!
also it was interesting to see that tramadol also processed by CYP2D6. doctor handed me a script for it, same day as handed the script for LDN, so never took the tramadol. good thing, sounds like it wouldn't have done me much good based on my lack of response to codeine. doctors never inquired about this. so in future if i am ever not on LDN and need a pain reliever, though things like codeine or tramadol may be safer than some of the stronger narcotics out there, wouldn't do me much good. good that the question of CYP2D6 has come up again; i had no idea about its action upon tramadol. so that in itself is useful information for me.
