yes, at the molecular level, the way she described the biologics and nsaids is correct. the nsaids block an enzyme along the pathway to making prostaglandins involved in the inflammatory process.
so i do know what is happening technically. but also the way mig explained about taking nsaids as maintenance to i guess you could say continually knock down the inflammation. maybe so it never becomes the cumulative effect that it does without an anti-inflammatory.
but for me (like i think so many), its all sort of academic anyway, since the nsaids seem to come with so many side effects: thus far i've tried 9 nsaids or cox2 inhibitors and either: they don't do much, make me really tired and give me brain fog, cause edema, or cause gastritis. think there is just one class left that i haven't tried. too bad that something that could be helpful comes with so many potential side effects. think that's the challenge of drugs in general for the inflammatory arthritises. so nothing new here.
but at least the topical nsaids seem to be locally somewhat effective without any thus far side effects! that was a nice surprise for me.
the more i learn about drugs, the more impressed i am anytime one is designed to do what it needs to do with minimal side effects!
