Hi Pea,

I inject methotrexate once a week and have tolerated it this way much better than when taking it orally.

It's very easy to do - my doctor gave me a lesson and then I did it in his office for the next two weeks before managing by myself at home.

I think it may be important to increase the dose of mtx very very slowly starting with a low dose - in my opinion, much lower than most doctors typically start you. I think that's why I had such success - I allowed my body lots of time to adjust to the drug and didn't try to rush it.

Donna - I don't believe injecting mtx is any easier on the liver - I still need the same regular liver tests. But it is easier on the digestive system and is less likely to cause nausea.

Wendy

Rheumatoid Arthritis
Methotrexate, Celebrex, Plaquenil