That is a question we all answer individually. Balance of life, meds and pain.
If taking meds, as others said important to have lab work monitored. CAn look at meds that have less side effects if they work... again, if taking meds, there will always be individual response on how best to balance meds and pain.
Other answer is looking at alternatives... diet, exercise, stretching... They can always be incorporated with meds so you have to take less meds.
Best to you,
Tim
