As I understand it, Reactive arthritis, if not caught early or treated fully may eventually turn into AS, or something resembling AS.
I'd suggest you give Humira a try. Theoretically, I imagine that an TNFa inhibitor could worsen Reactive arthritis if there was an infection going on, but I think you mentioned testing negative for all infections yet still have symptoms.
This class of meds has a good safety profile... I've been on one for 11+ yrs.
If it doesn't prove to help - then you can always choose to stop and try a different treatment approach. It is does help, then bonus!
