Kickas.org Forums Ankylosing Spondylitis General Discussion #1 AS Web Support Group NSAIDs - COX2 Inhibitors / Heads Up

www.sciencedaily.com/releases/2014/11/141105165053.htm

More evidence arthritis/pain relieving drugs may contribute to stroke death
Date:
November 5, 2014
Source:
American Academy of Neurology (AAN)
Summary:
Commonly prescribed, older drugs for arthritis and pain may increase the risk of death from stroke, according to a study. "Our study supports stepping up efforts to make sure people with a higher risk of stroke are not prescribed these medications when other options are available," authors concluded.

Commonly prescribed, older drugs for arthritis and pain may increase the risk of death from stroke, according to a study published in the November 5, 2014, online issue of Neurology®, the medical journal of the American Academy of Neurology. Stroke is the fourth leading cause of death in the United States, according to the Centers for Disease Control and Prevention.
The drugs examined in the study, called COX-2 inhibitors, include older drugs diclofenac, etodolac, nabumeton and meloxicam, as well as newer drugs called coxibs, including celecoxib and rofecoxib. COX-2 inhibitors are selective nonsteroidal anti-inflammatory drugs (NSAIDs). The study also looked at non-selective NSAIDs, which include common pain relievers such as ibuprofen and naproxen. (more...)

A total of 10,835 of the participants, or 11 percent, were NSAID users; 8,402, or 8 percent, were former users; and 80,806, or 81 percent, were non-users. Of the current NSAID users 51 percent used ibuprofen, 27 percent used diclofenac, 11 percent used etodolac, three percent naproxen, one percent celecoxib and 0.5 percent rofecoxib.
"Our study supports stepping up efforts to make sure people with a higher risk of stroke are not prescribed these medications when other options are available," said Schmidt.

Journal Reference:
Morten Schmidt, MD et al. Preadmission use of nonaspirin nonsteroidal anti-inflammatory drugs and 30-day stroke mortality. Neurology, November 2014 DOI: 10.1212/WNL.0000000000001024

Was it Vioxx that was taken off the market for these same problems?

Tim

Hi Tim, Yes. Vioxx was taken off the market due to cardiac side effects / deaths. Pharma paid out hundreds of thousands...

Yes but..
Uncontrolled inflammation in your body probably also cause serious cardiac and artery damage.

If I can find a way to control inflammation fully without NSAIDs I'd do it.

But until then, the choice between a shorter painful disabled life vs a shorter active life is an easy one for me to make.

FASTING; it's so worth it!

Wordbeter : Fasting, diet - also check out the Human Microbiome Research Project - note the interrelationship between gut / inflammation / autoimmune - supports Prof Ebringer's work of more than a couple of decades ago...

Also check out Low Dose Naltrexone, LDN. Curbs inflammation.

Here's another one, just in - Curcumin, has antiinflammatory effects :-

New research adds spice to curcumin's health-promoting benefits
Posted: 06 Nov 2014 08:32 AM PST
The health benefits of over-the-counter curcumin supplements might not get past your gut, but new research shows that a modified formulation of the spice releases its anti-inflammatory goodness throughout the body.

(snip...) "...researchers looked for further details about the compound's effects on inflammation. They found that nano-emulsified curcumin halted the recruitment of immune cells called macrophages that "eat" invading pathogens but also contribute to inflammation by secreting pro-inflammatory chemicals. And in cells isolated from human blood samples, macrophages were stopped in their tracks.
"This macrophage-specific effect of curcumin had not been described before," Young said. "Because of that finding, we propose nano-emulsified curcumin has the best potential against macrophage-associated inflammation."
Inflammation triggered by overactive macrophages has been linked to cardiovascular disease, disorders that accompany obesity, Crohn's disease, rheumatoid arthritis, inflammatory bowel disease, diabetes and lupus-related nephritis."

Ohio State University. "New research adds spice to curcumin's health-promoting benefits." ScienceDaily. ScienceDaily, 6 November 2014. <www.sciencedaily.com/releases/2014/11/141106113204.htm>.

Small warning about curcumin--it is a blood thinner. My daughter tried this one day and the next morning she awoke with two black eyes. Watch the dosage, especially if you also take fish oil, which also thins the blood.

Ginger also thins the blood... I put a few slivers of ginger in my boiling water that I add to my chamomile tea. Great taste... drink it couple of times a week now.

Tim

thanks for that molly,

and to add to the general discussion that is branching out from the original post.

i did try fish oil at "therapeutic" amounts: 3-4 grams per day of high quality fish oil (Nordic Naturals).

I stopped it when I started the humira. partly due to being tired of taking the huge pills. partly due to the expense (my most expensive supplement due to the amount i was taking).

but too, every so often, i was getting these "spontaneous blood vessel ruptures" as my GP called them. I'd get this sudden "bee sting feel" and then watch a bruise spontaneously form in that spot. Was basically hands, feet, but when I got one on my ankle the size of a quarter, it was enough to make me concerned. GP had me get a bunch of blood work to test for things like clotting factors, etc. but all the blood work came out ok. genetics testing might have turned something up (like EDS) and I might get that done some day because that could be useful to know (from what I've read). or it could have been due to inflammation of blood vessels, as i haven't had it happen since starting humira 1.5+ years ago.

but its highly likely it was due to the fish oil. my mom had to go to the emergency room due to a nose bleed that wouldn't stop. after that the doctors told her no more children's aspirin or fish oil "as prevention for her heart". and since i am her daughter, its possible the fish oil was doing this to me as well.

my fear was that a bigger, more important blood vessel would rupture.

thus far, out of all the things i've tried for inflammation (nsaids, cox2 inhibitors, fish oil, methylprednisone, biologic (humira), humira has worked the very best with at least short term, the fewest (as in no) side effects.

i do eat and drink a lot of ginger (ginger in stir fries and other dishes), lots of ginger tea. enough that it seems to keep my gastritis quiet. but probably not enough to cause the blood vessel problems that fish oil was causing.

just because something is "natural", doesn't mean its completely safe. Just because something is "man made", doesn't always mean its dangerous.

the other "safe" thing i've taken for inflammation seems to be the LDN. thus far (since sept 2009), it only seems to do good, with no noticeable side effects. while it has been great for the enthesitis, didn't seem to be doing enough? anything? on the other symptoms. thus why i started humira.

perhaps if cancer or MS ran in my family, then maybe the biologics wouldn't be as safe for me.

anyway, everything has "+'s" and "-'s"......