Kickas.org Forums Ankylosing Spondylitis General Discussion #1 AS Web Support Group coxibs - new developments, mixed blessings?

Hello NFN, you and I corresponded several years ago on the old site. I'm sending you best wishes, Evelyn

Same thought about the older NASIDs also supressing cox-2 prostoglandins popped into my head, but it seems the new cox-2 specific inhibitors are not only more specific, but more agressive in their depletion of cox-2 as well.

  Loz


  "Here comes the sun..."

Hey Cheryl!

You're bang on, that's exactly what I said. It would be neat if there was a therapy that addressed that specifically - it's a part of the deisease that no one know what to do with.

Hugs,
Jeanna

Live simply. Give more. Expect less.

Steve - whine all you want. In fact, whine more. When I heard the news, I was just too excited about the potential therapy, that I nearly forgot about the newest development in the side effects. Good to have someone keep me balanced --- I'm still just a little too young in science-years ... too much excites me right off the line.

Who knows though - perhaps there's a dose respone that slows new bone growth but allows for boney repair. Or, maybe a combination drug therapy will end up being of great benefit here.

Look at me, always giving birth to a healthy dose of scientific optimism.

You mixed sports metaphors?
Jeanna

Live simply. Give more. Expect less.

Hey jcwinnie.

Yes, the coxibs have been in the news alot because of the potential cardiovascular side effects. The latest theory is that they do not in themselves have cardiovascular side effects. Rather, by taking away cox-1 inhibition (preventing platelet aggregation), you have taken away some cardiovascular protection that people didnt know they had with the older NSAIDs.

As the abstracts you quote suggest, people with other risks for cardiovascular disease might consider taking a baby aspirin a day if they are on coxib therapy. Of course, you have to wonder if that negates the gastrointestinal benefit of cox-2s. Yikes. What a nightmare.

Jeanna

Live simply. Give more. Expect less.

Dear Kearly and Bilko.

Well, to answer your questions in a word - maybe. Helpful huh? Remember these are two very early papers done in mice. (poor little guys ).

My basic understanding from these two papers isnt that coxibs make you more at risk for osteoperosis - but the subsequent fractures you may sustain may take longer to heal. Can't really say certainly based on this info, but it would be something worth keeping an eye on, wouldnt it?

Good luck to both of you.
Jeanna

Live simply. Give more. Expect less.

Now look you............never mind ll this medicine stuff,,,,,,,,,,,,,want to know if you really considered the question when i asked you to marry me?? OK so i am unemployed
and have a bad leg
No money
and ugly
but why oh why should these be a bar to our blossoming relationship.........oh, forgot to say......my wife says it's ok...........XX

INEPTWILL....ANONYMOUS
SORRY FORGOT
PLEASE RUN AWAY WITH ME


LOL

Jeanna:

Khan in his web document, "Enthesitis and Ankylosis in Spondyloarthropathy," states:

"Ball, in his classic studies on enthesitis, suggested that the new bone formation is a reaction to the previous enostosis and repair of skeletal structures. For example, TGF-beta may provide protective signals early during the inflammatory process but induces nonspecific fibrosis upon chronic disease progression. Over-expression of some of these cytokines may induce pathologic ossification or promote degenerative disc degeneration. BMP-2 and BMP-4 promote callus formation in healing of bone fracture. BMP-2 also enhances tendon to bone healing, but the presence of BMP-7 is inappropriate for tendon repair because it may induce pathologic ossification. As noted earlier, BMP-6 transgenic mice develop florid periostitis, suggesting that this cytokine could be important in new bone formation."

So what's COX-1 got to do with it, huh?

Best regards,

jcwinnie

They do sell enteric(sp) coated low dose aspirin

Ron