I had my third infusion today and I don't really notice much difference either. I am still taking my other meds Indocine ,Vicodin, and Sulfasalazine. I was given higher dose today than the previous two. My M.D. want me to begin taking Methotrexate but I am a little scared about that. I really think that Remicade might have helped me had it been around twenty years ago. I'm 43 totaly fused, with no movement in my neck. I also have Crohn's Disease, which was in remission , but now has been acting up. I'm beginning to feel like an experiment.