I tired the Rutin, MSM, Omega 3, Primrose, Vit E, and a couple of others for a couple of weeks. I quit taking them all and other then a thicker wallet I notice no difference. My gut is healed nicely I believe and I attribute it more to the NSD then anything else. Perhaps the aloe juice helped, but who knows. I drank a couple gallons of it and still have a glass of it every day or two. Strict NSD for a couple months does alot of good.