Hi Mike,
I am a 24 female, I started taking enbrel in jan 2004 for A.S., 25mg twice a week. My rheumy told me to experiment with it. I tried going a few extra days in between shots and I I also tried doubling up on my dose with just one shot a week. Both had the same effect...I noticed that after the fourth day with out enbrel my body started to get a little stiffer, even when I was taking twice as much. The pain was nothing unbearable though just a stiffness. He figured if I could go longer inbetween shots it might save me some money. So my perfect dose of enbrel was 25mg on wed and 25mg on sat. My pain 99% disappeared. I love that drug!! I hope that helped a little.
-jamie
