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Finnari, what you say is true of "reactive" depression, and that's not what we are discussing.
Endogenous clinical depression is physical, just like AS.Your neurochemistry, for one reason or another, is all screwed up. For some reason our bodies leave excess serotonin bouncing around our brains, and that causes depression. It doesn't matter if you think good thoughts. It won't be fixed without the appropriate medication.