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Joined: Jun 2015
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Key Points
Microbial dysbiosis of gut commensals has been implicated in SpA and may provide an important link between SpA and gut inflammation.

Epithelial permeability, either as cause or effect of gut inflammation has been implicated in loss of mucosal tolerance.

Genetic factors and environmental triggers can concomitantly influence the gut microbiome promoting disease.

HLA-B27 transgenic rats with SpA develop subclinical or overt IBD and represent a robust model to dissect these interactions.

Cause and effect relationships between microbial dysbiosis and SpA may lead to the development of novel therapeutic approaches.

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I hope we get some really high quality probiotics and fmt stool drugs in the form of a pill in the future...


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