I guess I've been lucky. Most of the time, the NSAIDs work well for me. Not that I don't have some days with chest or back pain or stiff neck or every once in a while, sleepless or restless nights and sweats, but generally, I'm OK. Everything wil be fine for maybe a few years, then finally, the attack on my stomach and I have to quit the drugs for awhile and start some new one which has been developed in the meanwhile. Vioxx fell into that category. It is the first one which seemed to quite suddenly stop working for me.