Hey Joe!
First things first - welcome to KA! Hope you enjoy your time here. Thanks for your post in the pharmacy forum. FYI - this forum gets a lot less traffic, so when you're feeling like it, c'mon over to the Main Forum. I know about 500 people who are eager to meet you!
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As for your question about the Vioxx not working anymore, I lifted this from a post I've made previously in this thread (lazy, sorry).
'Everyone tells me that (switching meds is) not SUPPOSED to work, and that the change that I feel is only psychological. However, I truly feel a difference if I switch between NSAIDs every once in a while... Its not intentional - run out of Vioxx and have a few Mobic still kicking around kind of thing. Regardless, the drugs always feel more useful after I've had a bit of a break from them.'
I dont know what the reason is for this --- perhaps the mechanism of action of each drug is just a little bit different, despite all being NSAIDs. Perhaps your body does develop some of tolerance to a drug when its on it for a long time? Maybe (god forbid) your experiencing a nasty flare right now, and the drugs arent cutting the pain like they did before? I dont know, I'm only throwing ideas around ...
I would consider trying just switching meds for a bit. If your still trying to stay with the cox-2 inhibitors try Vioxx for a bit, or maybe even Mobic (although its not quite as selective for cox-2 as the other ones, it is moreso than the older drugs).
Regardless, let us know how things go for ya'! And like I said, dip your toe in the main forum as soon as you get a chance. The water's fine
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Jeanna
(Pharmacy Administrator)
Jeanna 
