This is my first posting. I was diagnosed with AS in 1976. Took quite a few doctors before someone finally nailed it. I've been switching NSAIDs as each eventually attacks my stomach. The latest one I went on is Vioxx, 50 mg daily. At first, it seemed to be working (i've only been on it maybe 5 months). Suddenly , last week, it felt like I was taking no medication. Chest aches, back aches. I would have thought I was on some kind of placebo. Never had this kind of reaction from any of the previous NSAIDs. Can't see the doctor until next Thursday and the extra strength Tyl just isn't doing much. When i'm out of pain and feeling good, it's hard to re-develop the pain tolerance again. Anybody had an NSAID stop working like that?
Joe
