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Betty, Sometimes when I inject, I heard the "bubble" sound myself. I guess that's normal. I didnt get the Enbrel, because they are so far behind in orders, so my doctor put me in Kineret shot. They are 1110 dollars for a 30 days prescription. I only pay a 9 dollar co-payment thru my insurance. These shots are like Enbrel man made protein with whatever else they have. I think I will keep taking them if they continue to make me feel this way. One more thing, I had an Uveitis flareup the day before I started on the shots. But it seem that my Uveitis is gone. Beside the normal drops and nite oitment I didnt use anything else. I dont know if the shot helped. My flareups of Uveitis stay with me for about three months. I just hope this Kineret helps with the Uveitis too!...See ya.